Polymorphism rs368234815 of interferon lambda 4 gene and spontaneous clearance of hepatitis C virus in haemodialysis patients: a case-control study

Abstract Background In non-uremic subjects, IFNL4 rs368234815 predicts HCV clearance. We investigated whether is associated with spontaneous clearance in haemodialysis patients and it a stronger predictor of resolution than the IFNL polymorphisms already dialysis subjects. also evaluated an association patients` survival alterations transcription factor binding sites (TFBS) caused by polymorphisms. Methods Among 161 positive anti-HCV antibodies, 68 (42.2%) spontaneously resolved infection, whereas 93 remained RNA positive. Patients were tested for near IFNL3 rs12980275, rs4803217, rs12979860, rs368234815, rs8099917. polymorphism (TT/TT, ΔG/TT, ΔG/ΔG) was genotyped restriction fragment length analysis; other - high melting curve analysis. used Kaplan-Meier method log-rank test silico analysis included use ENCODE TFBS ChIP-seq data, HOCOMOCO, JASPAR CORE, CIS-BP databases, FIMO software. Results The probability (OR, 95%CI, P) TT/TT higher ΔG allele carriers (2.63, 1.38–5.04, 0.003). This major homozygotes varied between 2.80, 1.45–5.43, 0.002 rs12980275 2.44, 1.27–4.69, 0.007 rs12979860. additive model, strongest (6.38, 1.69–24.2, Survival suggested mortality due to neoplasms (log-rank P = 0.005). ∆G removal PLAGL1. Conclusions patients, better that documented IFNL3/IFNL4 only mode inheritance. However, identifying homozygosity variant means more potent prediction persistent infection subjects we observe case / Removal PLAGL1 harbouring may contribute cancer susceptibility. cancer-related needs further studies HCV-exposed